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Oral estrogens are quickly broken down by the liver, and this "first pass" through the liver seems to be responsible for certain side effects as well as for the positive effects of oral estrogen on cholesterol levels, lowering LDL (the "bad" cholesterol) and raising HDL (the "good" cholesterol).
Lower doses of estrogens generally have fewer side effects than higher doses and may be effective for treating symptoms of menopause.There are also estradiol skin patches (transdermal estrogen), and some estrogen products can be used in the vagina. Most estrogen products delivered through the skin are bio-identical estrogens, but some oral and vaginal estrogens are not (e.g., Premarin, Ogen, Cenestin, Premarin vaginal cream).An estradiol skin gel (Estro Gel) is available in many countries including Canada and the U. The estrogen used in transdermal patches is bio-identical estrogen (estradiol); however, the estrogen used in the contraceptive skin patch (Ortho Evra) is a synthetic estrogen. The main forms of estrogen found in women's bodiesendogenous estrogenare: The amount of these estrogens in the body varies over the course of the menstrual cycle. Estrogens used in ERT, HRT and NHRT The differences between oral and transdermal estrogens Estrogen refers both to natural estrogen hormones in the body and estrogen products used in medications.Estriol is not often used in HRT, although it is possible to have an estrogen cream that contains estriol made to order by a compounding pharmacy.
Estriol, while much weaker than estradiol, is still able to cause systemic effects on the user, and studies have found that oral estriol can stimulate the endometrium.
The most commonly prescribed form of estrogen for HRT in the U. for many years has been a mixture of estrogens extracted from the urine of pregnant mares (Premarin, and the estrogen in Prempro and other estrogen products that begin with Prem-).
Prempro is the combined estrogen/progestin formulation that was found in the WHI study to be associated with a somewhat increased risk of breast cancer, heart attack, stroke, and blot clots.
Estrogen molecules bind, or attach, to estrogen receptors much like a key fits into a lock, and this leads to effects that vary from one body part to another.
Not all parts of the body have estrogen receptors, and not all estrogen receptors are alike.
In addition, the ovaries continue making small amounts of testosterone, which can be converted to estradiol.